Alpha-1 antitrypsin (AAT) reduces severity of Pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and Pseudomonas invasion of respiratory epithelial cells
Nosocomial pneumonia (NP) is the third most common hospital-acquired infection and the leading cause of death due to hospital-acquired infection in the US.During pneumonia and non-pneumonia severe illness, respiratory tract secretions become enriched with the serine essie tea and crumpets protease neutrophil elastase (NE).Several NE activities prom